The global market needs more than 2000 kinds of raw materials and pharmaceutical intermediates supporting chemical industry every year, with a demand of more than 2.5 million tons. After more than 30 years of development, the chemical raw materials and intermediates required for global pharmaceutical production can be basically matched, and only a small part needs to be imported. Moreover, due to the abundant global resources and the low price of raw materials, many intermediates have been exported in large quantities. What are the opportunities for global pharmaceutical development?
Increased demand
Global β－ After nearly 50 years of development, lactam antibiotics have formed a complete production system. Almost all in 2012 β－ Lactam antibiotics (except the varieties within the patent period) can be produced all over the global market , and the cost is very low. The output of penicillin ranks first in the global market , and a large number of them are exported to the international market; Cephalosporins are basically self-sufficient and can strive for some exports.
2012, and β－ All the pharmaceutical intermediates supporting lactam antibiotics can be produced by themselves all over the global market . Except that the mother nucleus 7-ACA and 7-ADCA of semi synthetic antibiotics need to be partially imported, all side chain intermediates can be produced and exported in large quantities.
with β－ Taking phenylacetic acid, the main supporting pharmaceutical intermediates of lactam antibiotics, as an example, there are nearly 30 phenylacetic acid manufacturers in the global market , with a total annual output capacity of about 20000 tons. However, most enterprises are small in scale, with the largest annual output of 2000 tons, and most of the others have an annual output of hundreds of tons. In 2003, China’s total demand for phenylacetic acid was about 14000 tons. The consumption structure was as follows: Penicillin G accounted for 85%, other medicines accounted for 4%, spices accounted for 7%, and pesticides and other fields accounted for 4%.
With the development of global perfume, medicine, pesticide and other industries, the demand for phenylacetic acid will further increase. It is estimated that by 2025, the global pharmaceutical industry will consume about 140000 tons of phenylacetic acid, the pesticide industry will consume 5000 tons and the spice industry will consume about 20000 tons. Coupled with the consumption in other fields, it is estimated that the total global demand for phenylacetic acid will reach 180000 tons in 2025.